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Description
7-DHC/DHCR7 Recombinant Rabbit mAb (S-3625-32)Product Specification Host Rabbit Antigen 7 DHC DHCR7 Synonyms 7 dehydrocholesterol reductase; Cholesterol 5,6 epoxide hydrolase subunit DHCR7; Sterol Delta (7) reductase; Dhcr7 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession O88455 Clone Number S 3625 32 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms, Rt Positive Sample Mouse testis, Mouse brain, Rat testis, Rat brain Purification Protein A Concentration 2
Product Specification
| Host | Rabbit |
| Antigen | 7-DHC/DHCR7 |
| Synonyms | 7-dehydrocholesterol reductase; Cholesterol-5,6-epoxide hydrolase subunit DHCR7; Sterol Delta (7)-reductase; Dhcr7 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | O88455 |
| Clone Number | S-3625-32 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms, Rt |
| Positive Sample | Mouse testis, Mouse brain, Rat testis, Rat brain |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
Background
7-Dehydrocholesterol (7-DHC) is a crucial sterol intermediate in the cholesterol biosynthesis pathway that serves as the direct precursor to cholesterol and the provitamin for vitamin D3 synthesis upon exposure to UVB radiation, while DHCR7 (7-dehydrocholesterol reductase) is the essential membrane-bound enzyme located in the endoplasmic reticulum that catalyzes the final step of this pathway by reducing the C7-C8 double bond of 7-DHC to produce cholesterol; together, they form a tightly regulated metabolic axis where genetic defects or inhibition of DHCR7 lead to the pathological accumulation of 7-DHC and its derivatives, causing severe developmental disorders such as Smith-Lemli-Opitz syndrome (SLOS) characterized by intellectual disability and congenital malformations, whereas under normal physiological conditions, the precise balance maintained by DHCR7 ensures adequate cellular cholesterol levels for membrane integrity and steroid hormone production while simultaneously controlling the pool of 7-DHC available for cutaneous photconversion to vitamin D3.
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